SUMOplot? Analysis Program
The SUMOplot? Analysis Program predicts and scores sumoylation sites in your protein. The presence of this post-translational modification may help explain larger MWs than expected on SDS gels due to attachment of SUMO protein (11kDa) at multiple positions in your protein.
SUMO-1 (small ubiquitin-related modifier; also known as PIC1, UBL1, Sentrin, GMP1, and Smt3) is a member of the ubiquitin and ubiquitin-like superfamily. Most SUMO-modified proteins contain the tetrapeptide motif B-K-x-D/E where B is a hydrophobic residue, K is the lysine conjugated to SUMO, x is any amino acid (aa), D or E is an acidic residue.
The SUMOplot? Analysis Program predicts the probability for the SUMO consensus sequence (SUMO-CS) to be engaged in SUMO attachment. The SUMOplot? score system is based on two criteria: direct amino acid match to SUMO-CS. substitution of the consensus amino acid residues with amino acid residues exhibiting similar hydrophobicity.
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